Isolation and characterization of a highly divergent HIV-2[GH-2]: Generation of an infectious molecular clone and functional analysis of its rev-responsive element in response to primate retrovirus transactivators (rev and rex)
Identifieur interne : 001462 ( Main/Exploration ); précédent : 001461; suivant : 001463Isolation and characterization of a highly divergent HIV-2[GH-2]: Generation of an infectious molecular clone and functional analysis of its rev-responsive element in response to primate retrovirus transactivators (rev and rex)
Auteurs : Meiko Kawamura [Japon] ; Jun Katahira [Japon] ; Masashi Fukasawa [Japon] ; Jun-Ichi Sakuragi [Japon] ; Koh-Ichi Ishikawa [Japon] ; Masuyo Nakai [Japon] ; Julius A. A. Mingle [Ghana] ; Mubarak Osei-Kwasi [Ghana] ; Victor B. A. Netty [Ghana] ; Hirofumi Akari [Japon] ; Osamu Hishida [Japon] ; Keizo Tomonaga [Japon] ; Tomoyuki Miura [Japon] ; Masanori Hayami [Japon]Source :
- Virology [ 0042-6822 ] ; 1992.
Descripteurs français
- KwdFr :
- ADN viral (génétique), Cartographie de restriction, Clonage moléculaire, Gènes pX, Gènes rev, Régulation de l'expression des gènes viraux, Répétition terminale longue du VIH, Similitude de séquences d'acides nucléiques, VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (génétique), Variation génétique.
- MESH :
- Pascal (Inist)
- Wicri :
- topic : Prototype.
English descriptors
- KwdEn :
- Binding sites, Clone, Cloning, Molecular, DNA, Viral (genetics), Effector plasmid, Gene Expression Regulation, Viral, Genes, pX, Genes, rev, Genetic Variation, HIV Long Terminal Repeat, HIV-2 (genetics), HIV-2 virus, Hayami, Kyoto university, LTR sequence, Molecular clone, Nucleotide sequence, Plasmid, Prototype, Proviral structure, Replication capacity, Restriction Mapping, Restriction map, Sakai, Sequence Homology, Nucleic Acid, Sequence data, Sequence database, Sequence diversity, Variant, Viral, Virus research.
- MESH :
- chemical , genetics : DNA, Viral.
- genetics : HIV-2.
- Cloning, Molecular, Gene Expression Regulation, Viral, Genes, pX, Genes, rev, Genetic Variation, HIV Long Terminal Repeat, Restriction Mapping, Sequence Homology, Nucleic Acid.
- Teeft :
Abstract
A highly divergent HIV-2 designated as HIV-2[GH-2] was obtained from an AIDS-related complex (ARC) patient in Ghana. A full-length molecular clone of this isolate was obtained and a biologically active clone was constructed. Its restriction pattern differed from that of prototype HIV-2[GH-1 ] in 25 of 35 restriction sites, but was strikingly similarto a previously characterized HIV-2 isolate from a Ghanaian (HIV-2ALT). The conserved integrase region (288-bp fragment) previously displayed 95% identity with that of ALT but 17–20% divergence from the HIV-2 prototype member, and a new distinct subgroup (HIV-2b) of HIV-2 consisting of GH-2 and ALT was postulated (Miura et al. 1991.) These isolates, however, were biologically distinguishable from each other by its replication capacity in a monocyte line, U937, in which GH-2 could not grow but ALT grew well. In addition, the nucleotide sequence of the LTR of this new isolate displays 21% divergence from that of prototype HIV-2[GH-1], but the core enhancer, Spl binding sites and TATA box were conserved. Although the 3' half of the env gene sequence which is deleted in HIV-2ALT clone showed 27% diversity from the prototype, functional differences in the rev-responsive element were not observed.
Url:
DOI: 10.1016/0042-6822(92)90540-6
Affiliations:
- Ghana, Japon
- Région de Kantō, Région du Grand Accra, Région du Kansai
- Accra, Kyoto, Tokyo
- Université de Kyoto, Université du Ghana
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Le document en format XML
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Department of Viral Infection, Institute of Medical Science, University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Katahira, Jun" sort="Katahira, Jun" uniqKey="Katahira J" first="Jun" last="Katahira">Jun Katahira</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Immunodeficiency Virus, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Fukasawa, Masashi" sort="Fukasawa, Masashi" uniqKey="Fukasawa M" first="Masashi" last="Fukasawa">Masashi Fukasawa</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Immunodeficiency Virus, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Sakuragi, Jun Ichi" sort="Sakuragi, Jun Ichi" uniqKey="Sakuragi J" first="Jun-Ichi" last="Sakuragi">Jun-Ichi Sakuragi</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Immunodeficiency Virus, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Ishikawa, Koh Ichi" sort="Ishikawa, Koh Ichi" uniqKey="Ishikawa K" first="Koh-Ichi" last="Ishikawa">Koh-Ichi Ishikawa</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Institute for Public Health, Yamanashi</wicri:regionArea><wicri:noRegion>Yamanashi</wicri:noRegion></affiliation></author><author><name sortKey="Nakai, Masuyo" sort="Nakai, Masuyo" uniqKey="Nakai M" first="Masuyo" last="Nakai">Masuyo Nakai</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka Medical College, Takatsuki, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Mingle, Julius A A" sort="Mingle, Julius A A" uniqKey="Mingle J" first="Julius A. A." last="Mingle">Julius A. A. Mingle</name><affiliation wicri:level="4"><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Osei Kwasi, Mubarak" sort="Osei Kwasi, Mubarak" uniqKey="Osei Kwasi M" first="Mubarak" last="Osei-Kwasi">Mubarak Osei-Kwasi</name><affiliation wicri:level="4"><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Netty, Victor B A" sort="Netty, Victor B A" uniqKey="Netty V" first="Victor B. A." last="Netty">Victor B. A. Netty</name><affiliation wicri:level="1"><country xml:lang="fr">Ghana</country><wicri:regionArea>St. Joseph Hospital, Koforidua</wicri:regionArea><wicri:noRegion>Koforidua</wicri:noRegion></affiliation></author><author><name sortKey="Akari, Hirofumi" sort="Akari, Hirofumi" uniqKey="Akari H" first="Hirofumi" last="Akari">Hirofumi Akari</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Immunodeficiency Virus, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Hishida, Osamu" sort="Hishida, Osamu" uniqKey="Hishida O" first="Osamu" last="Hishida">Osamu Hishida</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Immunodeficiency Virus, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Tomonaga, Keizo" sort="Tomonaga, Keizo" uniqKey="Tomonaga K" first="Keizo" last="Tomonaga">Keizo Tomonaga</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Immunodeficiency Virus, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Miura, Tomoyuki" sort="Miura, Tomoyuki" uniqKey="Miura T" first="Tomoyuki" last="Miura">Tomoyuki Miura</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Immunodeficiency Virus, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Hayami, Masanori" sort="Hayami, Masanori" uniqKey="Hayami M" first="Masanori" last="Hayami">Masanori Hayami</name><affiliation></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Immunodeficiency Virus, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">188</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="850">850</biblScope><biblScope unit="page" to="853">853</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Binding sites</term><term>Clone</term><term>Cloning, Molecular</term><term>DNA, Viral (genetics)</term><term>Effector plasmid</term><term>Gene Expression Regulation, Viral</term><term>Genes, pX</term><term>Genes, rev</term><term>Genetic Variation</term><term>HIV Long Terminal Repeat</term><term>HIV-2 (genetics)</term><term>HIV-2 virus</term><term>Hayami</term><term>Kyoto university</term><term>LTR sequence</term><term>Molecular clone</term><term>Nucleotide sequence</term><term>Plasmid</term><term>Prototype</term><term>Proviral structure</term><term>Replication capacity</term><term>Restriction Mapping</term><term>Restriction map</term><term>Sakai</term><term>Sequence Homology, Nucleic Acid</term><term>Sequence data</term><term>Sequence database</term><term>Sequence diversity</term><term>Variant</term><term>Viral</term><term>Virus research</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (génétique)</term><term>Cartographie de restriction</term><term>Clonage moléculaire</term><term>Gènes pX</term><term>Gènes rev</term><term>Régulation de l'expression des gènes viraux</term><term>Répétition terminale longue du VIH</term><term>Similitude de séquences d'acides nucléiques</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (génétique)</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV-2</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN viral</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2)</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cloning, Molecular</term><term>Gene Expression Regulation, Viral</term><term>Genes, pX</term><term>Genes, rev</term><term>Genetic Variation</term><term>HIV Long Terminal Repeat</term><term>Restriction Mapping</term><term>Sequence Homology, Nucleic Acid</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Carte restriction</term><term>Cartographie de restriction</term><term>Clonage moléculaire</term><term>Clone</term><term>Gènes pX</term><term>Gènes rev</term><term>Régulation de l'expression des gènes viraux</term><term>Répétition terminale longue du VIH</term><term>Similitude de séquences d'acides nucléiques</term><term>Séquence LTR</term><term>Variant</term><term>Variation génétique</term><term>Virus HIV2</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Binding sites</term><term>Clone</term><term>Effector plasmid</term><term>Hayami</term><term>Kyoto university</term><term>Molecular clone</term><term>Nucleotide sequence</term><term>Plasmid</term><term>Prototype</term><term>Proviral structure</term><term>Replication capacity</term><term>Sakai</term><term>Sequence data</term><term>Sequence database</term><term>Sequence diversity</term><term>Viral</term><term>Virus research</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prototype</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A highly divergent HIV-2 designated as HIV-2[GH-2] was obtained from an AIDS-related complex (ARC) patient in Ghana. A full-length molecular clone of this isolate was obtained and a biologically active clone was constructed. Its restriction pattern differed from that of prototype HIV-2[GH-1 ] in 25 of 35 restriction sites, but was strikingly similarto a previously characterized HIV-2 isolate from a Ghanaian (HIV-2ALT). The conserved integrase region (288-bp fragment) previously displayed 95% identity with that of ALT but 17–20% divergence from the HIV-2 prototype member, and a new distinct subgroup (HIV-2b) of HIV-2 consisting of GH-2 and ALT was postulated (Miura et al. 1991.) These isolates, however, were biologically distinguishable from each other by its replication capacity in a monocyte line, U937, in which GH-2 could not grow but ALT grew well. In addition, the nucleotide sequence of the LTR of this new isolate displays 21% divergence from that of prototype HIV-2[GH-1], but the core enhancer, Spl binding sites and TATA box were conserved. Although the 3' half of the env gene sequence which is deleted in HIV-2ALT clone showed 27% diversity from the prototype, functional differences in the rev-responsive element were not observed.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Japon</li></country><region><li>Région de Kantō</li><li>Région du Grand Accra</li><li>Région du Kansai</li></region><settlement><li>Accra</li><li>Kyoto</li><li>Tokyo</li></settlement><orgName><li>Université de Kyoto</li><li>Université du Ghana</li></orgName></list><tree><country name="Japon"><region name="Région du Kansai"><name sortKey="Kawamura, Meiko" sort="Kawamura, Meiko" uniqKey="Kawamura M" first="Meiko" last="Kawamura">Meiko Kawamura</name></region><name sortKey="Akari, Hirofumi" sort="Akari, Hirofumi" uniqKey="Akari H" first="Hirofumi" last="Akari">Hirofumi Akari</name><name sortKey="Fukasawa, Masashi" sort="Fukasawa, Masashi" uniqKey="Fukasawa M" first="Masashi" last="Fukasawa">Masashi Fukasawa</name><name sortKey="Hayami, Masanori" sort="Hayami, Masanori" uniqKey="Hayami M" first="Masanori" last="Hayami">Masanori Hayami</name><name sortKey="Hishida, Osamu" sort="Hishida, Osamu" uniqKey="Hishida O" first="Osamu" last="Hishida">Osamu Hishida</name><name sortKey="Ishikawa, Koh Ichi" sort="Ishikawa, Koh Ichi" uniqKey="Ishikawa K" first="Koh-Ichi" last="Ishikawa">Koh-Ichi Ishikawa</name><name sortKey="Katahira, Jun" sort="Katahira, Jun" uniqKey="Katahira J" first="Jun" last="Katahira">Jun Katahira</name><name sortKey="Kawamura, Meiko" sort="Kawamura, Meiko" uniqKey="Kawamura M" first="Meiko" last="Kawamura">Meiko Kawamura</name><name sortKey="Miura, Tomoyuki" sort="Miura, Tomoyuki" uniqKey="Miura T" first="Tomoyuki" last="Miura">Tomoyuki Miura</name><name sortKey="Nakai, Masuyo" sort="Nakai, Masuyo" uniqKey="Nakai M" first="Masuyo" last="Nakai">Masuyo Nakai</name><name sortKey="Sakuragi, Jun Ichi" sort="Sakuragi, Jun Ichi" uniqKey="Sakuragi J" first="Jun-Ichi" last="Sakuragi">Jun-Ichi Sakuragi</name><name sortKey="Tomonaga, Keizo" sort="Tomonaga, Keizo" uniqKey="Tomonaga K" first="Keizo" last="Tomonaga">Keizo Tomonaga</name></country><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Mingle, Julius A A" sort="Mingle, Julius A A" uniqKey="Mingle J" first="Julius A. A." last="Mingle">Julius A. A. Mingle</name></region><name sortKey="Netty, Victor B A" sort="Netty, Victor B A" uniqKey="Netty V" first="Victor B. A." last="Netty">Victor B. A. Netty</name><name sortKey="Osei Kwasi, Mubarak" sort="Osei Kwasi, Mubarak" uniqKey="Osei Kwasi M" first="Mubarak" last="Osei-Kwasi">Mubarak Osei-Kwasi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Isolation and characterization of a highly divergent HIV-2[GH-2]: Generation of an infectious molecular clone and functional analysis of its rev-responsive element in response to primate retrovirus transactivators (rev and rex)
}}
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